<i>In vitro</i> studies used LPS-stimulated primary astrocytes for RNA-seq and qPCR validation.<h4>Results</h4>Aged wild-type (18M+WT) mice exhibited specific deficits in Barnes maze retention and reversal learning, indicative of mild cognitive impairment, while Pank4-CKO mice showed significant rescue. The gene discussed is PANK4; the disease is Cognitive impairment.