Clinicopathological features and survival outcomes were assessed, and multivariate Cox regression was used to identify independent prognostic factors for melanoma-specific survival.<h4>Main outcome measures</h4>Melanoma-specific survival and its association with BAP1 nuclear expression and classical prognostic variables.<h4>Results</h4>Low grade nuclear BAP1 expression was detected in 50% of tumors and was significantly associated with worse melanoma-specific survival (hazard ratio [HR] = 2.72; 95% confidence interval [CI]: 1.04-7.11; p = 0.041). Here, BAP1 is linked to melanoma.