AIFM1 and intervertebral disk degenerative disorder: Molecular docking results showed that NVP-AEW541 and EGCG could bind to the AIFM1 protein with a binding free energy of -10.7 kcal/mol; WB confirmed protein trends.<h4>Conclusion</h4>The five-core-gene signature is strongly associated with IDD and may represent a key regulatory pathway, offering a promising diagnostic model and potential therapeutic targets.