<h4>Introduction</h4>Aortic valve sclerosis (AVSc) is an active pathological process driven by extracellular matrix remodeling, consistent with a potentially reversible early stage of aortic valve disease.<h4>Methods</h4>In this cross-sectional study of 168 participants (29, normal aortic valve [NAV]; 98, AVSc; 41, aortic stenosis [AS]), serum levels of matrix metalloproteinase (MMP)-1, -2, -3, and -9, tissue inhibitor of metalloproteinases-1 (TIMP-1), tumor necrosis factor (TNF), interleukin-6 (IL-6), and transforming growth factor-beta (TGF-β) were measured. The gene discussed is TNF; the disease is aortic stenosis.