However, the therapeutic potential of RCEO in PF and its underlying mechanisms remain to be elucidated.<h4>Purpose</h4>To investigate whether RCEO ameliorates pulmonary function in PF mice by suppressing the polarization of M1 and M2 macrophages via suppressing the Pi3k/Akt/β-catenin and Tlr4/Myd88/Nf-κb signaling pathways.<h4>Methods</h4>Bioinformatics and network pharmacology approaches were employed to predict the potential therapeutic targets of RCEO for PF. Here, NFKB1 is linked to pemphigus foliaceus.