The Global Mean Deviation (GMD) reached the highest diagnostic accuracy (AUC = 0.916), which was not significantly different from GDF + VUNO (p = 0.146).<h4>Conclusions</h4>Laguna ONhE and VUNO Med-Fundus AI had high diagnostic accuracy in detecting glaucoma using only CFP. The gene discussed is PAEP; the disease is glaucoma.