Furthermore, a cell line-derived xenograft animal model was utilized to confirm the roles of PRPS2 <i>in vivo</i>.<h4>Results</h4>An elevation of PRPS2 was observed in NSCLC samples, and its overexpression promoted NSCLC cell proliferation, while PRPS2 knockdown inhibited cell proliferation. The gene discussed is PRPS2; the disease is non-small cell lung carcinoma.