RHOA and osteoarthritis: <h4>Background</h4>Cartilage fibrosis plays a critical role in the onset and progression of osteoarthritis (OA), and although RhoA is a well-known small GTPase that regulates cytoskeletal reorganization, its role in OA progression remains inadequately explored.<h4>Methods</h4>In this study, we first screened public scRNA-seq datasets for genes enriched in fibrocartilage chondrocytes and found that <i>RHOA</i> is significantly upregulated in fibrocartilage chondrocytes within OA cartilage obtained from patients undergoing total knee arthroplasty.