Furthermore, nine unrelated patients harbored nine variants within six susceptibility genes associated with YOPD, including EIF4G1, COQ2, TENM4, NR4A2, UQCRC1, and GBA1.<h4>Conclusion</h4>This study is the first to analyze the genetic spectrum and clinical characteristics of patients with YOPD in the Hakka population of western Fujian Province. The gene discussed is EIF4G1; the disease is young-onset Parkinson disease.