Furthermore, nine unrelated patients harbored nine variants within six susceptibility genes associated with YOPD, including EIF4G1, COQ2, TENM4, NR4A2, UQCRC1, and GBA1.<h4>Conclusion</h4>This study is the first to analyze the genetic spectrum and clinical characteristics of patients with YOPD in the Hakka population of western Fujian Province. This evidence concerns the gene NR4A2 and young-onset Parkinson disease.