METTL3 and Hepatic fibrosis: Molecular docking identified saxagliptin as a potential METTL3-binding compound, which reduced AFB<sub>1</sub>-induced HSC activation and extracellular matrix accumulation, consistent with the effects of STM2457.<h4>Conclusions</h4>These findings indicate that METTL3 functions as a post-transcriptional regulator in AFB<sub>1</sub>-induced liver fibrosis via m<sup>6</sup>A modification.