Molecular docking was performed to identify potential METTL3-binding compounds, followed by functional validation.<h4>Results</h4>AFB<sub>1</sub> exposure promoted hepatic fibrosis and HSC activation, accompanied by global m<sup>6</sup>A hypermethylation and upregulation of METTL3. This evidence concerns the gene METTL3 and Hepatic fibrosis.