To address this gap, we assessed fine-scaled genetic overlap between SSc and commonly associated cancers, namely breast and lung cancers, as well as hematologic malignancies, by applying local genetic correlation analyses.<h4>Methods</h4>We assessed the genetic relationship between SSc and cancers that frequently co-occur with SSc: breast cancer and its' four main molecular subtypes: HER2-enriched-like, luminal A and B-like, and triple-negative breast cancers, as well as lung cancer, lymphocytic leukemia, and non-Hodgkin's lymphoma. This evidence concerns the gene ERBB2 and breast cancer.