<h4>Objective</h4>To investigate the correlations of various clinical indicators, fibroblast growth factor 23 (FGF23), and Apelin-13 with osteoporosis (OP) and diabetic peripheral neuropathy (DPN) in postmenopausal women with type 2 diabetes mellitus (T2DM), and to evaluate their predictive value for OP and DPN.<h4>Methods</h4>A total of 320 postmenopausal women were enrolled, including 238 patients with T2DM and 82 non-diabetic patients with OP. This evidence concerns the gene APLN and osteoporosis.