The characteristic clinical phenotype of OP patients with comorbid T2DM was also summarized.<h4>Results</h4>In postmenopausal women with T2DM, 25OH-VitD and Apelin-13 were independently associated with higher T-scores (protective factors), while PTH, CPT scores, and FGF23 were independently associated with lower T-scores (risk factors). This evidence concerns the gene APLN and type 2 diabetes mellitus.