This study evaluates a novel strategy combining X-ray irradiation, MFH, and engineered magnetic nanoparticles to improve treatment efficacy in lung cancer.<h4>Methods</h4>Carbon-encapsulated iron nanoparticles (Fe@C), coated with polyethyleneimine (PEI) and functionalized with a monoclonal IgG antibody targeting the β3 subunit (CD61) of the αvβ3 integrin receptor, were loaded with glucose oxidase (GOX) to produce Fe@C-PEI-IgG-GOX nanoparticles. Here, HAO1 is linked to lung carcinoma.