TREH and nonpapillary renal cell carcinoma: The clinical relevance, immunological landscape, and biological functions of the top candidate were systematically characterized using scRNA-seq analysis and validated through extensive <i>in vitro</i> and <i>in vivo</i> assays.<h4>Results</h4>Trehalase (TREH) was identified as a novel, independent protective factor for ccRCC.