GLP1R and type 2 diabetes mellitus: While sodium-glucose co-transporter 2 inhibitors (SGLT2i) may exert beneficial effects on cardiac autonomic function, it remains uncertain whether baseline SGLT2i use is associated with attenuation of GLP-1 RA-related HRV decline in T2DM.<h4>Methods</h4>In this prospective observational study, 45 patients with T2DM were divided into two groups according to pre-study dapagliflozin use: a dapagliflozin-naïve group (Control group, n=22) and a dapagliflozin-exposed group (DAPA group, n=23).