<h4>Background</h4>The objective of this study was to assess whether interleukin-17 or 18 (IL-17 or IL-18), regulatory T cells (Tregs), and T helper17 (Th17) serum concentrations were different in chronic heart failure not associated with myocarditis compared to healthy individuals.<h4>Methods</h4>We searched MEDLINE and Embase for studies with data on IL-17 or IL-18 serum concentrations in patients with chronic heart failure. This evidence concerns the gene IL18 and congestive heart failure.