The pooled mean difference was 251.59 pg/mL (95% CI: 177.24-325.93 pg/mL) with a random effects model.<h4>Conclusion</h4>Serum IL-17, IL-18 Th17, and Treg count have utility for risk stratification for patients with heart failure, as biomarkers for heart failure severity and potential target pathways for treatment. This evidence concerns the gene IL17A and heart failure.