The most frequent manifestations were ocular dryness (91.9%), oral dryness (78.4%), anti-SSA antibodies (Ro52: 51.4%; Ro60 kDa: 54.1%), antinuclear antibodies (ANA) titers >1:160 (64.9%), rheumatoid factor (RF) positivity (40.5%), elevated erythrocyte sedimentation rate (ESR) (67.6%), and arthralgia (56.8%). Here, TRIM21 is linked to Arthralgia.