We evaluated the expression of <i>S1PR1</i>, <i>S1PR3</i>, <i>SPHK1</i>, and <i>SPHK2</i> by real-time quantitative reverse transcription PCR (RT-qPCR) in four groups (n = 41-42 each): women without HIV (WWoH) with term birth (≥37 weeks of gestation; TB), WWoH with spontaneous preterm birth (<37 weeks of gestation, sPTB), women with HIV (WWH) with TB, and WWH with sPTB. This evidence concerns the gene SPTB and tuberculosis.