FLT3 and acute myeloid leukemia: <b>Results</b>: Among these, compounds <b>MA190</b> and <b>MA191</b>, containing rigid cyclohexyl-piperidine/piperazine linkers, demonstrate superior degradation of FLT3-ITD in MV4-11 AML cells at nanomolar concentrations, achieving >95% reduction in FLT3-ITD levels, outperforming <b>MA49</b>.