In the present study, we found that kujiol A prevented the transcription of interferon-γ (IFN-γ), interleukin (IL)-2, IL-4, and Fas ligand in T-box transcription factor Eomesodermin (Eomes)-transfected murine T cell lymphoma BW5147 cells stimulated with phorbol ester and ionomycin (a calcium ionophore). This evidence concerns the gene IL4 and T-cell non-Hodgkin lymphoma.