BRD2 and neurodegenerative disease: Furthermore, through their inhibitory target effect on NLRP3, these two extracts and the bioactive compounds (NAT and ERG), like BB, are attractive therapeutic molecules to reduce mood disorders related to brain aging, due to evidence of enhanced Nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing-3 (NLRP3) inflammasome activity in common neurodegenerative diseases.