FAP is expressed broadly on activated mesenchymal cells-including cancer-associated fibroblasts (CAFs) and myofibroblasts within desmoplastic tumor stroma, FAP-positive tumor cells in selected sarcomas, and activated fibroblasts in chronic fibroinflammatory disorders such as rheumatoid arthritis, Crohn's disease, and organ fibrosis. This evidence concerns the gene FAP and cancer.