RT-qPCR results showed predominant non-significant expression of VIM, ACTA2, and <i>FGFR1</i> in unicystic ameloblastoma compared to other ameloblastoma types.<h4>Conclusion</h4>The significantly higher immunoexpression of SOX2 and CD44 in conventional subtypes could suggest a greater presence of TSCs, and predominant VIM, ACTA2, and <i>FGFR1</i> gene expression in unicystic ameloblastoma could suggest the possibility of EMT processes related to cystic formation. The gene discussed is VIM; the disease is ameloblastoma.