Herein, it is shown that <i>SYTL4</i> mRNA expression is significantly (<i>p</i> = 2.01 × 10<sup>-4</sup>) diminished in breast cancer bearing <i>BRCA1</i> mutations, suggesting a mechanistic interplay between <i>BRCA1</i>-driven genomic instability and <i>SYTL4</i>-regulated signaling cascades. Here, BRCA1 is linked to breast cancer.