MYH11 and neurofibromatosis type 1: We analyze the role of genes involved in vascular smooth muscle cell contractility (<i>ACTA2</i>, <i>MYH11</i>), TGF-β signaling, and DNA repair mechanisms that drive MMS, alongside the genetic basis of syndromic forms associated with neurofibromatosis type 1, trisomy 21, and RASopathies.