Hsa-miR-21-5p enhanced proliferation and viability of KT21-MG1 meningioma cells and showed a regulatory effect on <i>IL6R</i>, <i>IL6ST</i> and other predicted target genes <i>TIMP3</i>, <i>PIK3R</i>, <i>RHOB</i>, and <i>SASH1</i> by interacting with 3'UTRs. The gene discussed is RHOB; the disease is meningioma.