For individual cancer types, values of <i>p</i> = 0.0071 for ovarian, <i>p</i> = 0.0028 for endometrial, and <i>p</i> = 0.0269 for cervical cancers were obtained; Our preliminary study suggests that the rs6725958 and rs1968510 <i>FN1</i> variants may slightly increase the risk of female reproductive system cancers, particularly ovarian cancer. Here, FN1 is linked to cervical cancer.