Functionalization with FA (ZnFe<sub>2</sub>O<sub>4</sub>/HNT/Cp/FA) promoted amide bond linkage, modulated Cp-FA interactions, and significantly enhanced cumulative Cp release compared to the non-functionalized system ZnFe<sub>2</sub>O<sub>4</sub>/HNT/Cp (10.3% at 72 h vs. 34.4% at 72 h) under tumor acidic conditions (pH 6.6). This evidence concerns the gene CP and neoplasm.