APLN and osteomyelitis: This study aimed to evaluate serum SIRT1, SIRT3, apelin, and elabela (ELA) levels in patients with DFI and to examine their cross-sectional associations with clinical indicators, inflammatory markers, osteomyelitis, and glycemic control.<h4>Methods</h4>This cross-sectional study included 47 patients with DFI and 42 healthy controls.