Furthermore, <i>Perilla frutescens</i>-derived vesicles modulate the JAK-STAT pathway, demonstrating a potential reduction of Interleukin-6 (IL-6) by 40% and a downregulation of CYP1A1 expression by up to 49% in cell models, thereby suggesting a capacity to mitigate oxidative stress and pruritus.<h4>Conclusions</h4>By integrating these components into a "Triple-Action" framework, focusing on immunomodulation, structural restoration, and precision signaling, this review provides a comprehensive roadmap for promising dermo-cosmetic interventions in atopic skin management. This evidence concerns the gene CYP1A1 and Pruritus.