Topological analysis of the protein-protein interaction (PPI) network revealed ten critical hub proteins-GAPDH, IL6, EGFR, HSP90AA1, NFKB1, HSP90AB1, MTOR, MAPK3, IL2, and PIK3CA-which serve as key regulators in CKD pathophysiology. This evidence concerns the gene MAPK3 and chronic kidney disease.