PLOD2 and Biemond syndrome type 2: <b>Background/Objectives</b>: Bruck syndrome type 2 (BS2) is an ultra-rare autosomal recessive disorder within the osteogenesis imperfecta (OI) spectrum caused by biallelic pathogenic variants in <i>PLOD2</i>, which encodes lysyl hydroxylase 2 (LH2), an enzyme essential for bone-specific collagen cross-linking.