<b>Results</b>: Across analyses, two variants in <i>ASTN2</i> (rs1052053 and rs6478241) showed the most robust associations with migraine, surviving Bonferroni correction in the joint model (<i>p</i> = 0.001 and <i>p</i> = 0.002, respectively) and false discovery rate (FDR) correction in marginal models (q = 0.003 for both). The gene discussed is ASTN2; the disease is migraine disorder.