This study examines the level of GPIHBP1 to assess its diagnostic and prognostic values across the metabolic continuum.<h4>Methods</h4>This is an observational monocentric study, including 160 patients with type 2 diabetes mellitus, obesity without carbohydrate metabolism disorders and healthy controls. Here, GPIHBP1 is linked to obesity due to melanocortin 4 receptor deficiency.