GPIHBP1 and obesity due to melanocortin 4 receptor deficiency: The statistical analyses included <i>t</i>-tests, Pearson's correlation analysis, and ROC analysis to explore associations and the predictive values of the biomarker.<h4>Results</h4>The GPIHBP1 levels increased progressively, with the lowest levels observed in the control group, higher levels in patients with obesity, and the highest levels in those with diabetes mellitus.