The statistical analyses included <i>t</i>-tests, Pearson's correlation analysis, and ROC analysis to explore associations and the predictive values of the biomarker.<h4>Results</h4>The GPIHBP1 levels increased progressively, with the lowest levels observed in the control group, higher levels in patients with obesity, and the highest levels in those with diabetes mellitus. Here, GPIHBP1 is linked to obesity disorder.