Serum nesfatin-1 was markedly elevated in patients with epilepsy compared to HCs (44.04 (interquartile range 38.19-76.72) vs. 8.65 (interquartile range 7.82-9.01) ng/mL, <i>p</i> < 0.001; ~5-fold). Here, NUCB2 is linked to epilepsy.