A significant inverse correlation between serum nesfatin-1 and GOAT levels was identified in patients with epilepsy (rho = -0.68, 95% CI [-0.86, -0.36], <i>p</i> < 0.001) but not in HCs (<i>p</i> = 0.53) and remained independent of age, sex, body mass index and epilepsy type. This evidence concerns the gene NUCB2 and epilepsy.