CDKL5 and Anxiety: We demonstrate that <i>Cdkl5</i> knockout mice exhibit reproducible and region-specific disruptions in brain network organization, prominently affecting the somatosensory and somatomotor cortex, hippocampus, hypothalamus, amygdala, and superior colliculus-regions implicated in cognition, learning and memory, homeostasis, anxiety, and visual-motor function.