(2) Tracking analysis of B cell receptor clonality and effector molecule expression revealed that in SLE, dual BCR B cells tend to enrich in IFN-α/γ responses, TNF-NFκB inflammation, and complement pathways, and highly express interferon-related genes such as <i>Ly6a</i>, <i>Isg15</i>, <i>MX1</i>, and <i>IFI6</i>. Here, LY6S is linked to systemic lupus erythematosus.