The molecular mechanisms underlying the modulation of mucociliogenesis following IL-4/13 blockade with dupilumab remain poorly understood, notwithstanding its proven clinical efficacy.<h4>Methods</h4>Bulk RNA Barcoding and sequencing (BRB-seq) was performed on nasal polyp tissues collected from healthy controls (<i>n</i> = 6), patients with non-ECRS (<i>n</i> = 8), and patients with ECRS both before and four weeks after dupilumab treatment (<i>n</i> = 9) to identify the early molecular drivers underlying ciliary regeneration. This evidence concerns the gene IL4 and Nasal polyposis.