Gene-expression arrays were performed on vessel walls of MA patients and controls.<h4>Results</h4>RNF213-RNAi impaired angiogenic capability in ECs, whereas the simultaneous silencing of RNF213 and its phosphatase PTP1B restored angiogenesis function in ECs but worsened it in VSMCs. The gene discussed is PTPN1; the disease is microtia.