GJA1 and Arrhythmia: Additionally, SIM significantly attenuated the overexpression of Cx43 and its phosphorylated form (p<sup>S368</sup>Cx43), which are responsible for impairing intercellular communication and electrical coupling in cardiomyocytes and contribute to arrhythmias and conduction abnormalities characteristic of acute Doxo-induced cardiotoxicity.