High POU6F1 expression was significantly associated with younger age (<i>p</i> = 0.027), female sex (<i>p</i> = 0.041), non-smoking status (<i>p</i> = 0.002), adenocarcinoma histology (<i>p</i> = 0.021), and the presence of EGFR mutations (<i>p</i> = 0.038). Here, EGFR is linked to adenocarcinoma.