APOE and Alzheimer disease: Furthermore, the <i>TOMM40</i> (rs2075650) was significantly associated with AD as a binary outcome (<i>p</i> = 4.60 × 10<sup>-24</sup>) and <i>APLP2</i> (rs12281267, rs959354), <i>APOE</i> (rs405509), <i>PTPRD</i> (rs1353983, rs970347, rs1392511) were associated with AD (<i>p</i> < 0.001).