Additionally, several pathways including the <i>ERBB4</i> signaling pathway (adjusted <i>p</i> = 2.82 × 10<sup>-3</sup>), driven by <i>ERBB4</i>, <i>NRG1</i>, and <i>NRG3</i> may contribute to cognitive impairments. The gene discussed is NRG3; the disease is Cognitive impairment.