Baseline blood count profiles differed across <i>LAG3</i> genotypes, suggesting a link between <i>LAG3</i> rs870849 and disease-associated levels of anemia, thrombocytopenia and peripheral blast percentage.<h4>Conslusions</h4>The germline <i>LAG3</i> variant rs870849 may be associated with AML disease risk and specific hematological disease features. This evidence concerns the gene LAG3 and anemia (phenotype).