Low TAM density showed a non-significant trend in the same direction.<h4>Conclusions</h4>Our findings generate the hypothesis that WHO grade II meningiomas exhibit an inverse relationship between TAMs and B7-H3 and that macrophage-poor/B7-H3-high and macrophage-rich/B7-H3-low patterns may differ in preoperative growth behavior. The gene discussed is CD276; the disease is meningioma.