Here, we identified kinesin family member 11 (KIF11) as a critical effector of DHA.<h4>Methods</h4>Bioinformatic analyses revealed that KIF11 is significantly upregulated in HCC and associated with poor prognosis, and gene expression profiling suggested its oncogenic role via the PI3K/Akt pathway. Here, AKT1 is linked to hepatocellular carcinoma.