This study investigated the protective role of quercetin, a natural flavonoid, in OTM-associated periodontitis and its underlying mechanism involving macrophage metabolic reprogramming via the IL-17/Hippo/YAP axis.<h4>Material and methods</h4>An in vivo OTM model was established using YAP-wild-type and YAP-knockout Sprague-Dawley rats to assess the effects of quercetin on periodontal inflammation and alveolar bone resorption. This evidence concerns the gene IL17A and periodontitis.