These effects were reversed upon YAP overexpression, confirming the pivotal role of the IL-17/Hippo/YAP axis in quercetin-mediated metabolic modulation.<h4>Conclusions</h4>Quercetin alleviates OTM-associated periodontitis by inhibiting the IL-17/Hippo/YAP signaling pathway, thereby suppressing macrophage aerobic glycolysis. Here, IL17A is linked to periodontitis.