Significant correlations were found between a CSI score ≥ 40 and female sex (<i>p</i> = 0.004), the occurrence of enthesitis (<i>p</i> = 0.05), DAPSA-CRP (<i>p</i> = 0.02) and ASDAS scores (<i>p</i> = 0.03), a multi-failure condition (<i>p</i> = 0.01), fibromyalgia (FM) (<i>p</i> = 0.004), thyroid disease (<i>p</i> = 0.016) and obesity (<i>p</i> = 0.047). This evidence concerns the gene CRP and obesity due to melanocortin 4 receptor deficiency.