Additionally, gut microbiota composition and the levels of short-chain fatty acids were determined.<h4>Results</h4>ZJMP treatment significantly ameliorated hyperglycemia and dyslipidemia, elevated serum insulin levels, reduced intestinal mucosal permeability, and attenuated histopathological lesions in the heart, kidney, and pancreas of T2DM rats. This evidence concerns the gene INS and Hyperglycemia.