Subsequently, the diet-induced obesity group received an injection of AAV-shGFRAL to knock down the GFRAL receptor.<h4>Results</h4>In obesity resistant mice, ectopic lipid deposition in the kidneys was markedly reduced, accompanied by decreased expression of the renal injury marker KIM-1 and significantly elevated levels of GDF15. The gene discussed is GDF15; the disease is obesity due to melanocortin 4 receptor deficiency.