Given the pivotal role of GDF15 in lipid metabolism, this study aims to determine whether GDF15 can ameliorate ectopic lipid deposition and mitigate the resulting renal injury.<h4>Methods</h4>C57BL/6J mice were used to establish a high-fat diet-induced obesity model. Here, GDF15 is linked to obesity due to melanocortin 4 receptor deficiency.