Ang-(1-7) intervention decreased blood glucose (<i>p</i> < 0.05) and CRP levels (<i>p</i> < 0.01), and alleviated dyslipidemia (<i>p</i> < 0.05 or <i>p</i> < 0.01), as well as β-cell morphology and insulin expression in obese T2DM mice. The gene discussed is CRP; the disease is metabolic syndrome.